Please use this identifier to cite or link to this item: https://hdl.handle.net/10419/220049 
Year of Publication: 
2020
Series/Report no.: 
Tinbergen Institute Discussion Paper No. TI 2020-012/II
Publisher: 
Tinbergen Institute, Amsterdam and Rotterdam
Abstract: 
The likelihood of cancer emergence is highly dependent on the underlying tissue structure. This article gives evolutionary explanations for why natural selection fails to select for tissue structures that would minimize the likelihood of cancer. In a second step, a mathematical framework is proposed, within which the risk of cancer emergence can be expressed and calculated dependent on a given tissue structure. This can be used to identify optimal structures and strategies for improvement. Lastly, the article explores both, ways to identify target areas for such intervention, as well as avenues towards developing treatment options.
Subjects: 
Evolution
Evolutionary Game Theory
Cancer
JEL: 
Z00
C73
I10
Document Type: 
Working Paper

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